Two major pharmacological actions of amphetamines include CNS stimulation and sympathomimetic effects. Long-term use of amphetamines is associated with myonecrosis, cardiomyopathy, and myocardial infarction. Several studies conclude that amphetamine abuse is strongly associated with coronary artery disease and with subarachnoid hemorrhages. This is seen particularly in the left frontal cortex which can lead to hemorrhages and other forms of strokes. Amphetamines cause tachycardia and hypertension and can cause significant cerebral blood flow which increases by 30%. Tachycardia and other arrhythmias are due to the sympathomimetic effects of amphetamines. Catecholamine levels are also elevated in amphetamine overdose causing increased energy and increased stimulation with decreased lethargy. Amphetamine toxicity can also cause seizures due to neuronal death from the interaction between amphetamines and NMDA receptors. Increased dopamine levels in the central nervous system (CNS) cause psychosis, euphoric effects, and other movement disorders. Elevated serotonin can affect the hypothalamus and thereby, cause hyperthermia. However, they also induce the release of epinephrine, serotonin, and histamine. Amphetamines increase the activity of the neurotransmitters dopamine and norepinephrine. Amphetamines are lipid soluble and thereby crosses the blood-brain barrier rapidly after ingesting or injecting. They cause an increase in biogenic amines that originate from the neuronal synaptic terminals, which in turn inhibit the reuptake of certain neurotransmitters. This can take a detrimental toll on an individual’s body as there are long-term effects of amphetamine abuse which include damage to nerve cells, seizures, gross psychosis, strokes, and dysrhythmias.Īmphetamines stimulate the central and peripheral nervous system. For these reasons, amphetamines can be very addicting both psychologically as well as physically due to the stimulating effects. The high from amphetamines can make users feel increased amounts of energy, confidence, and sense of clarity. There is always a high risk for amphetamine overdose due to its addiction potential. This is the consequence of both down regulations of the postsynaptic receptors and depletion of presynaptic stores of neurotransmitter. The etiology is unclear however, binging can be related to tolerance in which the user may require higher and higher doses to get the same effect. Patients who smoke or inject METH experience a strong “flash” which sometimes potentiate drug addiction with adverse health outcomes. According to the National Institute on Drug Abuse, smoking METH is the most common way of abuse. METH comes in different forms and can be smoked, inhaled, injected, or orally consumed. Amphetamine toxicity generally occurs in the setting of recreational use.
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Additionally, I will introduce some excellent tools.Īs you know, I am a big fan of using keybindings to boost my productivity. In this blog, I am going to explain how I moved on to Sierra. Karabiner elements key repeat professional#I pointed out one of the professional characteristics that I have lacked for a long time – problem-solving in an objective way. src/vendor/Karabiner-DriverKit-VirtualHIDDevice/dist/Karabiner-DriverKit-VirtualHIDDevice-*.dmg Sparkle.In my previous blog What I learned from upgrading to Sierra. The make script will create a redistributable Karabiner-Elements-VERSION.dmg in the current directory. export PQRS_ORG_INSTALLER_CODE_SIGN_IDENTITY=C86BB5F7830071C7B0B07D168A9A9375CC2D02C5 Build a package by executing the following command in Terminal.app. Set environment variable to use your codesign identity for installer signing. security find-identity -p basic -v | grep 'Developer ID Installer' export PQRS_ORG_CODE_SIGN_IDENTITY=8D660191481C98F5C56630847A6C39D95C166F22įind your codesign identity for installer signing. Set environment variable to use your codesign identity. security find-identity -p codesigning -v | grep 'Developer ID Application' Karabiner elements key repeat update#Git submodule update -init -recursive -depth 1 (Optional) If you have a codesign identity: Find your codesign identity. Karabiner elements key repeat install#macOS 11+ Xcode 13.1+ Command Line Tools for Xcode (xcode-select -install) xz (brew install xz) XcodeGen (brew install xcodegen) CMake (brew install cmake) Get source code by executing the following command in Terminal.app. Please follow the instruction of these projects. If you want to rebuild these binaries, you have to build them manually. (These binaries will be copied in the distributed package.). The above make package command does not rebuild these binaries. Karabiner-Elements uses some pre-built binaries in the source tree. System requirements to build Karabiner-Elements. Karabiner elements key repeat download#You can download Karabiner-Elements from the official site. If(MACH_PORT_VALID(service)) IOObjectRelease(service) If(MACH_PORT_VALID(client)) IOServiceClose(client) LOG("extSetStateForSelector: %s", mach_error_string(ret)) Ret = IOConnectCallScalarMethod(client, kIOHIDParam_extSetStateForSelector, in, 2, NULL, NULL) Kern_return_t IOConnectCallScalarMethod(io_connect_t client, uint32_t selector, const uint64_t *in, uint32_t inCnt, uint64_t *out, uint32_t *outCnt) Ĭonst uint32_t kIOHIDParamConnectType = 1 Ĭonst uint32_t kIOHIDActivityUserIdle = 3 Ĭonst uint32_t kIOHIDParam_extSetStateForSelector = 6 Kern_return_t IOServiceClose(io_connect_t client) Kern_return_t IOServiceOpen(io_service_t service, task_t task, uint32_t type, io_connect_t *client) Io_service_t IOServiceGetMatchingService(mach_port_t master, CFDictionaryRef matching CF_RELEASES_ARGUMENT) Kern_return_t IOObjectRelease(io_object_t object) ĬFMutableDictionaryRef IOServiceMatching(const char *name) CF_RETURNS_RETAINED clang -o t t.c -Wall -O3 -framework CoreFoundation -framework IOKitĮxtern const mach_port_t kIOMasterPortDefault #pragma clang diagnostic ignored "-Wdeprecated-declarations" * It's deprecated, but there's no better alternative. * This prevents the screen saver, but doesn't wake from display sleep. IOPMAssertionDeclareUserActivity(CFSTR("Wine user input"), kIOPMUserActiveLocal, &assertion) * This wakes from display sleep, but doesn't affect the screen saver. Sometimes I think the best way to support others is to leave them alone and allow them to be. I want to give others space and permission to share their authentic selves. I want to share my authentic thoughts and feelings. I don't like fake, and I don't want to share fake. My goal (for my writing and my life) is to be real. I'm primarily a writer, but I also create beautiful little collages hand make hemp jewelry and warm, colorful winter hats and use my creative and artistic skills to decorate my life and brighten the lives of others. I'm also a house and pet sitter, and I pick up odd jobs when I can. During the last two seasons as a work camper on that mountain, I was a clerk in a campground store. I was a camp host and parking lot attendant for two seasons and wrote a book about my experiences called Confessions of a Work Camper: Tales from the Woods. I was a work camper in a remote National Forest recreation area on a mountain for four seasons. When it gets too hot for me in my desert, I get in my minivan and move up in elevation to find cooler temperatures or I house sit in town in a place with air conditioning Now I have a little travel trailer parked in a small RV park in a small desert town. For almost half of the time I was a van dweller, I was going it alone. I've been a rubber tramp for nearly a decade.I like to see places I've never seen before, and I like to visit the places I love again and again.įor most of my years on the road, my primary residence was my van. In any case, that's the name I'm using here and now. Maybe that's the name my family gave me maybe it's not. If you camp at Bighorn, please pack out everything you packed in. Please! Do not leave the burnt remains of garbage in the fire pit as previous campers at the site I chose had done. Visitors need to carry out all their trash. #Boondocking in new mexico free#Like most free campgrounds, Bighorn has no trash receptacles. The door to the toilet closed and locked, and I was happy about that. There was an uncomfortable number of dead flies on the interior walls of the building, but I did my best to ignore them. There was plenty of toilet paper during my stay (but I advise you to always be prepared with your own). The pit toilet was a cute, rustic little building. However, the price (free) was right, and it was a good, close place to spend the night after I wore myself out hiking at The Catwalk. Have I stayed in prettier or more interesting places? Yes. There’s not really too much to say about this campground. I thought it would have been nice to have the sound of water as my backdrop, but I guess I was too late in the year. I checked out the arroyo back there when I arrived, and it was bone dry. I read somewhere (probably on a Free Campsites website review) that during some parts of the year water flows in a creek along the back edge of the campground. The dry, yellow grass can be seen near the trees. I had to park this far away from the picnic table in order to find a flat spot. The trees did offer some shade on the sites, but it wasn’t the shade of a pine forest. The grass was dry and yellow and did not grow on the actual campsites. There were trees in the campground (juniper and cedar, I think), and scrubby desert bushes. The road through the campground was dirt covered in gravel and the sites had sparse wood mulch and gravel spread over them. When I left at 5:30 the next morning, I saw a couple other vehicles that had pulled in during the night.Įach campsite had a heavy, difficult to move picnic table made of metal, as well as a manufactured metal fire pit. At dusk, a man on a bicycle arrived and set up a tent. It wasn’t difficult to pick a spot away from others, as there was only one other person in the campground when I arrived. Other sites looked flatter, but I was interested in being as far away from other campers as possible. I had to park my minivan 15 feet or so from the picnic table on the site in order to find adequate flatness for sleeping inside my rig. The sites seemed mostly flat, but are really designed for tent camping. Highway 180 is on the right (passenger side) of Silver Streak, on the other side of that mound of earth. |
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